Nebivolol Impurity 44
(1R,2R)-2-(N,N-Dimethylamino)-1-(p-nitrophenyl)-1,3-propanediol
CAS: 18867-45-3
Molecular Formula: C11H16N2O4
Nebivolol Impurity 44 - Names and Identifiers
Nebivolol Impurity 44 - Physico-chemical Properties
| Molecular Formula | C11H16N2O4 |
| Molar Mass | 240.26 |
| Density | 1.284±0.06 g/cm3(Predicted) |
| Boling Point | 418.6±45.0 °C(Predicted) |
| pKa | 12.90±0.20(Predicted) |
| Physical and Chemical Properties | Chemical properties This product is a light yellow powdery solid, m.p.101 ℃, insoluble in water. |
| Use | Use L-( )2-N,N. Dimethylamino-4-nitrophenyl -1, 3-propanediol, abbreviated as methylchloromyamine, is a resolving agent of (±) trans-Chrysanthemum acid,(±) CIS, trans-dichloro-Chrysanthemum acid, etc. |
Nebivolol Impurity 44 - Upstream Downstream Industry
| Raw Materials | aminoformic acid |
Nebivolol Impurity 44 - Reference Information
| Use | L-( )2-N,N. Dimethylamino-4-nitrophenyl -1, 3-propanediol, abbreviated as methylchloromyamine, is a resolving agent of (±) trans-Chrysanthemum acid,(±) CIS, trans-dichloro-Chrysanthemum acid, etc. |
| production method | the preparation method is to add the measured L-() into a three-mouth bottle with stirring and condenser. Chloromyamine, formic acid, formaldehyde, heated to reflux temperature reaction, heat preservation for 3H, decompression to remove the remaining formic acid, formaldehyde, residual liquid diluted with water, under the condition of cooling, alkali is added until the pH value reaches a certain value. After the solid is precipitated, the product is filtered and protected from light. |
Last Update：2024-04-09 15:16:45
Nebivolol Impurity 44 - Production method
the preparation method is to add measured L-() chloramilamide, formic acid and formaldehyde into a three-mouth bottle equipped with stirring and condenser, raise the temperature to reflux temperature for reaction, keep the temperature for 3 hours, remove the remaining formic acid and formaldehyde under reduced pressure, dilute the residual liquid with water, add alkali until the pH value reaches a certain value under cooling, filter after solid precipitation, and avoid light to obtain the product.
Last Update：2024-04-09 20:48:19
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Product Name: Nebivolol Impurity 44 Visit Supplier Webpage Request for quotationCAS: 18867-45-3
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
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Raw Materials for Nebivolol Impurity 44